The CCN Family Proteins: Modulators of Bone Development and Novel Targets in Bone-Associated Tumors

The CCN family of proteins is composed of six extracellular matrix-associated proteins that play crucial roles in skeletal development, wound healing, fibrosis, and cancer. Members of the CCN family share four conserved cysteine-rich modular domains that trigger signal transduction in cell adhesion,...

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Bibliographic Details
Main Authors: Po-Chun Chen, Hsu-Chen Cheng, Shun-Fa Yang, Chiao-Wen Lin, Chih-Hsin Tang
Format: Article
Language:English
Published: Hindawi Limited 2014-01-01
Series:BioMed Research International
Online Access:http://dx.doi.org/10.1155/2014/437096

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