Comparison of numerical simulations to experiments for atomization in a jet nebulizer.
The development of jet nebulizers for medical purposes is an important challenge of aerosol therapy. The performance of a nebulizer is characterized by its output rate of droplets with a diameter under 5 µm. However the optimization of this parameter through experiments has reached a plateau. The pu...
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doaj-c619a0cb97a54e9e9aba5bf47455470b2020-11-25T02:35:20ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-01811e7865910.1371/journal.pone.0078659Comparison of numerical simulations to experiments for atomization in a jet nebulizer.Nicolas LelongLaurent VecellioYann Sommer de GélicourtChristian TanguyPatrice DiotAlexandra Junqua-MoulletThe development of jet nebulizers for medical purposes is an important challenge of aerosol therapy. The performance of a nebulizer is characterized by its output rate of droplets with a diameter under 5 µm. However the optimization of this parameter through experiments has reached a plateau. The purpose of this study is to design a numerical model simulating the nebulization process and to compare it with experimental data. Such a model could provide a better understanding of the atomization process and the parameters influencing the nebulizer output. A model based on the Updraft nebulizer (Hudson) was designed with ANSYS Workbench. Boundary conditions were set with experimental data then transient 3D calculations were run on a 4 µm mesh with ANSYS Fluent. Two air flow rate (2 L/min and 8 L/min, limits of the operating range) were considered to account for different turbulence regimes. Numerical and experimental results were compared according to phenomenology and droplet size. The behavior of the liquid was compared to images acquired through shadowgraphy with a CCD Camera. Three experimental methods, laser diffractometry, phase Doppler anemometry (PDA) and shadowgraphy were used to characterize the droplet size distributions. Camera images showed similar patterns as numerical results. Droplet sizes obtained numerically are overestimated in relation to PDA and diffractometry, which only consider spherical droplets. However, at both flow rates, size distributions extracted from numerical image processing were similar to distributions obtained from shadowgraphy image processing. The simulation then provides a good understanding and prediction of the phenomena involved in the fragmentation of droplets over 10 µm. The laws of dynamics apply to droplets down to 1 µm, so we can assume the continuity of the distribution and extrapolate the results for droplets between 1 and 10 µm. So, this model could help predicting nebulizer output with defined geometrical and physical parameters.http://europepmc.org/articles/PMC3823843?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Nicolas Lelong Laurent Vecellio Yann Sommer de Gélicourt Christian Tanguy Patrice Diot Alexandra Junqua-Moullet |
spellingShingle |
Nicolas Lelong Laurent Vecellio Yann Sommer de Gélicourt Christian Tanguy Patrice Diot Alexandra Junqua-Moullet Comparison of numerical simulations to experiments for atomization in a jet nebulizer. PLoS ONE |
author_facet |
Nicolas Lelong Laurent Vecellio Yann Sommer de Gélicourt Christian Tanguy Patrice Diot Alexandra Junqua-Moullet |
author_sort |
Nicolas Lelong |
title |
Comparison of numerical simulations to experiments for atomization in a jet nebulizer. |
title_short |
Comparison of numerical simulations to experiments for atomization in a jet nebulizer. |
title_full |
Comparison of numerical simulations to experiments for atomization in a jet nebulizer. |
title_fullStr |
Comparison of numerical simulations to experiments for atomization in a jet nebulizer. |
title_full_unstemmed |
Comparison of numerical simulations to experiments for atomization in a jet nebulizer. |
title_sort |
comparison of numerical simulations to experiments for atomization in a jet nebulizer. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2013-01-01 |
description |
The development of jet nebulizers for medical purposes is an important challenge of aerosol therapy. The performance of a nebulizer is characterized by its output rate of droplets with a diameter under 5 µm. However the optimization of this parameter through experiments has reached a plateau. The purpose of this study is to design a numerical model simulating the nebulization process and to compare it with experimental data. Such a model could provide a better understanding of the atomization process and the parameters influencing the nebulizer output. A model based on the Updraft nebulizer (Hudson) was designed with ANSYS Workbench. Boundary conditions were set with experimental data then transient 3D calculations were run on a 4 µm mesh with ANSYS Fluent. Two air flow rate (2 L/min and 8 L/min, limits of the operating range) were considered to account for different turbulence regimes. Numerical and experimental results were compared according to phenomenology and droplet size. The behavior of the liquid was compared to images acquired through shadowgraphy with a CCD Camera. Three experimental methods, laser diffractometry, phase Doppler anemometry (PDA) and shadowgraphy were used to characterize the droplet size distributions. Camera images showed similar patterns as numerical results. Droplet sizes obtained numerically are overestimated in relation to PDA and diffractometry, which only consider spherical droplets. However, at both flow rates, size distributions extracted from numerical image processing were similar to distributions obtained from shadowgraphy image processing. The simulation then provides a good understanding and prediction of the phenomena involved in the fragmentation of droplets over 10 µm. The laws of dynamics apply to droplets down to 1 µm, so we can assume the continuity of the distribution and extrapolate the results for droplets between 1 and 10 µm. So, this model could help predicting nebulizer output with defined geometrical and physical parameters. |
url |
http://europepmc.org/articles/PMC3823843?pdf=render |
work_keys_str_mv |
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