Haploid genetic screens identify SPRING/C12ORF49 as a determinant of SREBP signaling and cholesterol metabolism
The transcription factor SREBP is a well-studied and major regulator of sterol and fatty acid metabolism. Here, the authors used haploid genetic screens to identify the Golgi-resident protein SPRING as a new modulator of SREBP by regulating the level of functional SREBP cleavage-activating protein (...
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Bibliographic Details
| Main Authors: |
Anke Loregger,
Matthijs Raaben,
Joppe Nieuwenhuis,
Josephine M. E. Tan,
Lucas T. Jae,
Lisa G. van den Hengel,
Sebastian Hendrix,
Marlene van den Berg,
Saskia Scheij,
Ji-Ying Song,
Ivo J. Huijbers,
Lona J. Kroese,
Roelof Ottenhoff,
Michel van Weeghel,
Bart van de Sluis,
Thijn Brummelkamp,
Noam Zelcer |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2020-02-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-020-14811-1
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