Fiber Optic Sensor for Real-time Monitoring of Freezing–Thawing Cycle in Cryosurgery

Cryosurgery/cryotherapy is a widely used, freezing−thawing technique for the renewal or destruction of pathological tissues by applying localized rapid cooling; however, it still relies on the subjective “expert knowledge” of the physicians without, up to now, real-time...

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Main Authors:	Dimosthenis Spasopoulos, George Rattas, Archontis Kaisas, Thomas Dalagiannis, Ioannis D. Bassukas, Nikolaos Kourkoumelis, Aris Ikiades
Format:	Article
Language:	English
Published:	MDPI AG 2020-02-01
Series:	Applied Sciences
Subjects:	optical scattering optical diffusion skin cryosurgery optical fiber sensors
Online Access:	https://www.mdpi.com/2076-3417/10/3/1053

id	doaj-c60d297d99234357b20cfb00dcbc1529
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spelling	doaj-c60d297d99234357b20cfb00dcbc15292020-11-25T02:20:25ZengMDPI AGApplied Sciences2076-34172020-02-01103105310.3390/app10031053app10031053Fiber Optic Sensor for Real-time Monitoring of Freezing–Thawing Cycle in CryosurgeryDimosthenis Spasopoulos0George Rattas1Archontis Kaisas2Thomas Dalagiannis3Ioannis D. Bassukas4Nikolaos Kourkoumelis5Aris Ikiades6Department of Physics, University of Ioannina, 45110 Ioannina, GreeceDepartment of Physics, University of Ioannina, 45110 Ioannina, GreeceDepartment of Physics, University of Ioannina, 45110 Ioannina, GreeceDepartment of Physics, University of Ioannina, 45110 Ioannina, GreeceDepartment of Skin & Venereal Diseases, School of Health Sciences, University of Ioannina, 45110 Ioannina, GreeceDepartment of Medical Physics, School of Health Sciences, University of Ioannina, 45110 Ioannina, GreeceDepartment of Physics, University of Ioannina, 45110 Ioannina, GreeceCryosurgery/cryotherapy is a widely used, freezing−thawing technique for the renewal or destruction of pathological tissues by applying localized rapid cooling; however, it still relies on the subjective “expert knowledge” of the physicians without, up to now, real-time monitoring of the treatment. This work focused on assessing the depth of freezing using optical transmission and backscattering measurements from frozen/unfrozen porcine ex-vivo skin samples. An optical fiber-array sensor was subsequently developed to determine the depth of freezing and the associated kill zone during freeze−thawing cycles with sub-millimeter accuracy within the skin tissue.https://www.mdpi.com/2076-3417/10/3/1053optical scatteringoptical diffusionskincryosurgeryoptical fiber sensors
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Dimosthenis Spasopoulos George Rattas Archontis Kaisas Thomas Dalagiannis Ioannis D. Bassukas Nikolaos Kourkoumelis Aris Ikiades
spellingShingle	Dimosthenis Spasopoulos George Rattas Archontis Kaisas Thomas Dalagiannis Ioannis D. Bassukas Nikolaos Kourkoumelis Aris Ikiades Fiber Optic Sensor for Real-time Monitoring of Freezing–Thawing Cycle in Cryosurgery Applied Sciences optical scattering optical diffusion skin cryosurgery optical fiber sensors
author_facet	Dimosthenis Spasopoulos George Rattas Archontis Kaisas Thomas Dalagiannis Ioannis D. Bassukas Nikolaos Kourkoumelis Aris Ikiades
author_sort	Dimosthenis Spasopoulos
title	Fiber Optic Sensor for Real-time Monitoring of Freezing–Thawing Cycle in Cryosurgery
title_short	Fiber Optic Sensor for Real-time Monitoring of Freezing–Thawing Cycle in Cryosurgery
title_full	Fiber Optic Sensor for Real-time Monitoring of Freezing–Thawing Cycle in Cryosurgery
title_fullStr	Fiber Optic Sensor for Real-time Monitoring of Freezing–Thawing Cycle in Cryosurgery
title_full_unstemmed	Fiber Optic Sensor for Real-time Monitoring of Freezing–Thawing Cycle in Cryosurgery
title_sort	fiber optic sensor for real-time monitoring of freezing–thawing cycle in cryosurgery
publisher	MDPI AG
series	Applied Sciences
issn	2076-3417
publishDate	2020-02-01
description	Cryosurgery/cryotherapy is a widely used, freezing−thawing technique for the renewal or destruction of pathological tissues by applying localized rapid cooling; however, it still relies on the subjective “expert knowledge” of the physicians without, up to now, real-time monitoring of the treatment. This work focused on assessing the depth of freezing using optical transmission and backscattering measurements from frozen/unfrozen porcine ex-vivo skin samples. An optical fiber-array sensor was subsequently developed to determine the depth of freezing and the associated kill zone during freeze−thawing cycles with sub-millimeter accuracy within the skin tissue.
topic	optical scattering optical diffusion skin cryosurgery optical fiber sensors
url	https://www.mdpi.com/2076-3417/10/3/1053
work_keys_str_mv	AT dimosthenisspasopoulos fiberopticsensorforrealtimemonitoringoffreezingthawingcycleincryosurgery AT georgerattas fiberopticsensorforrealtimemonitoringoffreezingthawingcycleincryosurgery AT archontiskaisas fiberopticsensorforrealtimemonitoringoffreezingthawingcycleincryosurgery AT thomasdalagiannis fiberopticsensorforrealtimemonitoringoffreezingthawingcycleincryosurgery AT ioannisdbassukas fiberopticsensorforrealtimemonitoringoffreezingthawingcycleincryosurgery AT nikolaoskourkoumelis fiberopticsensorforrealtimemonitoringoffreezingthawingcycleincryosurgery AT arisikiades fiberopticsensorforrealtimemonitoringoffreezingthawingcycleincryosurgery
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Fiber Optic Sensor for Real-time Monitoring of Freezing–Thawing Cycle in Cryosurgery

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