Recurrent Multiple Squamous Cell Carcinomas on the Scalp in a Patient with Juvenile Dermatomyositis

Recurrent Multiple Squamous Cell Carcinomas on the Scalp in a Patient with Juvenile Dermatomyositis

Both long-term administration of immunosuppressive agents and chronic inflammatory conditions, such as autoimmune disease, could be risk factors for the development of cutaneous squamous cell carcinoma (cSCC). In this report, we present a case of recurrent multiple cSCC on the scalp in a patient wit...

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Main Authors: Yota Sato, Taku Fujimura, Yumi Kambayashi, Akira Tsukada, Takanori Hidaka, Kayo Tanita, Takahiro Haga, Akira Hashimoto, Setsuya Aiba
Format: Article
Language:English
Published: Karger Publishers 2017-01-01
Series:Case Reports in Oncology
Subjects:
Carcinogenesis
Cutaneous squamous cell carcinoma
IL-17/IL-17R
Signaling
Online Access:http://www.karger.com/Article/FullText/456001
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spelling doaj-c60bf438573c480dad43d10eb93a4bc52020-11-25T00:25:46ZengKarger PublishersCase Reports in Oncology1662-65752017-01-0110110611110.1159/000456001456001Recurrent Multiple Squamous Cell Carcinomas on the Scalp in a Patient with Juvenile DermatomyositisYota SatoTaku FujimuraYumi KambayashiAkira TsukadaTakanori HidakaKayo TanitaTakahiro HagaAkira HashimotoSetsuya AibaBoth long-term administration of immunosuppressive agents and chronic inflammatory conditions, such as autoimmune disease, could be risk factors for the development of cutaneous squamous cell carcinoma (cSCC). In this report, we present a case of recurrent multiple cSCC on the scalp in a patient with juvenile dermatomyositis who had been administered cyclosporine and Predonine since she was a 1-year-old infant. Interestingly, immunohistochemical staining revealed IL-17-producing cells adjacent to IL-17R-expressing atypical keratinocytes. Our present case suggested that IL-17/IL-17R signaling might contribute to the carcinogenesis of cSCC.http://www.karger.com/Article/FullText/456001CarcinogenesisCutaneous squamous cell carcinomaIL-17/IL-17RSignaling
collection DOAJ
language English
format Article
sources DOAJ
author Yota Sato
Taku Fujimura
Yumi Kambayashi
Akira Tsukada
Takanori Hidaka
Kayo Tanita
Takahiro Haga
Akira Hashimoto
Setsuya Aiba
spellingShingle Yota Sato
Taku Fujimura
Yumi Kambayashi
Akira Tsukada
Takanori Hidaka
Kayo Tanita
Takahiro Haga
Akira Hashimoto
Setsuya Aiba
Recurrent Multiple Squamous Cell Carcinomas on the Scalp in a Patient with Juvenile Dermatomyositis
Case Reports in Oncology
Carcinogenesis
Cutaneous squamous cell carcinoma
IL-17/IL-17R
Signaling
author_facet Yota Sato
Taku Fujimura
Yumi Kambayashi
Akira Tsukada
Takanori Hidaka
Kayo Tanita
Takahiro Haga
Akira Hashimoto
Setsuya Aiba
author_sort Yota Sato
title Recurrent Multiple Squamous Cell Carcinomas on the Scalp in a Patient with Juvenile Dermatomyositis
title_short Recurrent Multiple Squamous Cell Carcinomas on the Scalp in a Patient with Juvenile Dermatomyositis
title_full Recurrent Multiple Squamous Cell Carcinomas on the Scalp in a Patient with Juvenile Dermatomyositis
title_fullStr Recurrent Multiple Squamous Cell Carcinomas on the Scalp in a Patient with Juvenile Dermatomyositis
title_full_unstemmed Recurrent Multiple Squamous Cell Carcinomas on the Scalp in a Patient with Juvenile Dermatomyositis
title_sort recurrent multiple squamous cell carcinomas on the scalp in a patient with juvenile dermatomyositis
publisher Karger Publishers
series Case Reports in Oncology
issn 1662-6575
publishDate 2017-01-01
description Both long-term administration of immunosuppressive agents and chronic inflammatory conditions, such as autoimmune disease, could be risk factors for the development of cutaneous squamous cell carcinoma (cSCC). In this report, we present a case of recurrent multiple cSCC on the scalp in a patient with juvenile dermatomyositis who had been administered cyclosporine and Predonine since she was a 1-year-old infant. Interestingly, immunohistochemical staining revealed IL-17-producing cells adjacent to IL-17R-expressing atypical keratinocytes. Our present case suggested that IL-17/IL-17R signaling might contribute to the carcinogenesis of cSCC.
topic Carcinogenesis
Cutaneous squamous cell carcinoma
IL-17/IL-17R
Signaling
url http://www.karger.com/Article/FullText/456001
work_keys_str_mv AT yotasato recurrentmultiplesquamouscellcarcinomasonthescalpinapatientwithjuveniledermatomyositis
AT takufujimura recurrentmultiplesquamouscellcarcinomasonthescalpinapatientwithjuveniledermatomyositis
AT yumikambayashi recurrentmultiplesquamouscellcarcinomasonthescalpinapatientwithjuveniledermatomyositis
AT akiratsukada recurrentmultiplesquamouscellcarcinomasonthescalpinapatientwithjuveniledermatomyositis
AT takanorihidaka recurrentmultiplesquamouscellcarcinomasonthescalpinapatientwithjuveniledermatomyositis
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AT takahirohaga recurrentmultiplesquamouscellcarcinomasonthescalpinapatientwithjuveniledermatomyositis
AT akirahashimoto recurrentmultiplesquamouscellcarcinomasonthescalpinapatientwithjuveniledermatomyositis
AT setsuyaaiba recurrentmultiplesquamouscellcarcinomasonthescalpinapatientwithjuveniledermatomyositis
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