Highly Efficient Conversion of Motor Neuron-Like NSC-34 Cells into Functional Motor Neurons by Prostaglandin E<sub>2</sub>

Highly Efficient Conversion of Motor Neuron-Like NSC-34 Cells into Functional Motor Neurons by Prostaglandin E<sub>2</sub>

Motor neuron diseases are a group of progressive neurological disorders that degenerate motor neurons. The neuroblastoma × spinal cord hybrid cell line NSC-34 is widely used as an experimental model in studies of motor neuron diseases. However, the differentiation efficiency of NSC-34 cells to neuro...

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Bibliographic Details
Main Authors: Hiroshi Nango, Yasuhiro Kosuge, Masaki Sato, Yoshiyuki Shibukawa, Yuri Aono, Tadashi Saigusa, Yoshihisa Ito, Kumiko Ishige
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Cells
Subjects:
prostaglandin E<sub>2</sub>
motor neuron
neuronal differentiation
neurite outgrowth
voltage-gated sodium current
action potential
Online Access:https://www.mdpi.com/2073-4409/9/7/1741

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