Metal Homeostasis Regulators Suppress FRDA Phenotypes in a Drosophila Model of the Disease.
Friedreich's ataxia (FRDA), the most commonly inherited ataxia in populations of European origin, is a neurodegenerative disorder caused by a decrease in frataxin levels. One of the hallmarks of the disease is the accumulation of iron in several tissues including the brain, and frataxin has bee...
Main Authors: | Sirena Soriano, Pablo Calap-Quintana, José Vicente Llorens, Ismael Al-Ramahi, Lucía Gutiérrez, María José Martínez-Sebastián, Juan Botas, María Dolores Moltó |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2016-01-01
|
Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC4951068?pdf=render |
Similar Items
-
TORC1 Inhibition by Rapamycin Promotes Antioxidant Defences in a Drosophila Model of Friedreich's Ataxia.
by: Pablo Calap-Quintana, et al.
Published: (2015-01-01) -
The Role of Iron in Friedreich’s Ataxia: Insights From Studies in Human Tissues and Cellular and Animal Models
by: José Vicente Llorens, et al.
Published: (2019-02-01) -
Drosophila melanogaster Models of Metal-Related Human Diseases and Metal Toxicity
by: Pablo Calap-Quintana, et al.
Published: (2017-07-01) -
Overexpression of human and fly frataxins in Drosophila provokes deleterious effects at biochemical, physiological and developmental levels.
by: Juan A Navarro, et al.
Published: (2011-01-01) -
Frataxin mRNA Isoforms in FRDA Patients and Normal Subjects: Effect of Tocotrienol Supplementation
by: Provvidenza Maria Abruzzo, et al.
Published: (2013-01-01)