| Summary: | Orthodontic treatment with fixed appliances that is mediated by the power forces of the apparatus might lead to changes in the blood circulation, predispose to a number of complications such as tooth movement and contributes to the morphological bone tissue remodeling. We have investigated 126 patients aged 16–35 years after appliance bracket therapy that has caused orthodontically induced gingival hyperplasia. Immunological investigation which comprised the study of the cellular immune system in patients with orthodontically induced gingival hyperplasia suggested that there were significant disorders of the cellular immune system that correspond to the T-suppressor type of the secondary immunodeficiency state. Endogenous interferon composed of a low molecular weight organic compounds and an interferon-inducing agent (isonicotinic acid derivative) was used in the treatment of the patients with orthodontically induced gingival hyperplasia. Interferon provides restoration of functional activity in T-lymphocytes, enhances the functional capacity of the macrophages, provides normalization of the cell immunity, contributes to the elimination of secondary immunodeficiency and restoration of immunological homeostasis in individuals with orthodontically induced gingival hyperplasia caused by fixed appliances.
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