Managing Evidence from Multiple Gene Finding Resources via an XML-based Integration Architecture

• Main Authors: Malousi Andigoni, Koutkias Vassilis, Maglaveras Nicos
• Format: Article
• Language: English
• Published: De Gruyter 2005-12-01
• Series: Journal of Integrative Bioinformatics
• Online Access: https://doi.org/10.1515/jib-2005-16

While biological processes underlying gene expression are still under experimental research, computational gene prediction techniques have reached high level of sophistication with the employment of efficient intrinsic and extrinsic methods that identify protein-coding regions within query genomic sequences. Their ability though to delineate the exact exon boundaries is characterized by a trade off between sensitivity and specificity and still is prone to alternations in gene regulation during transcription and splicing and to inherent complexities introduced by the implemented methodology. Evaluation studies have shown that combinatorial approaches exhibit improved accuracy levels through the integration of evidence data from multiple resources that are further assessed in order to end up with the most probable gene assembly.