Differential radiosensitivity phenotypes of DNA-PKcs mutations affecting NHEJ and HRR systems following irradiation with gamma-rays or very low fluences of alpha particles.

Differential radiosensitivity phenotypes of DNA-PKcs mutations affecting NHEJ and HRR systems following irradiation with gamma-rays or very low fluences of alpha particles.

We have examined cell-cycle dependence of chromosomal aberration induction and cell killing after high or low dose-rate γ irradiation in cells bearing DNA-PKcs mutations in the S2056 cluster, the T2609 cluster, or the kinase domain. We also compared sister chromatid exchanges (SCE) production by ver...

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Bibliographic Details
Main Authors: Yu-Fen Lin, Hatsumi Nagasawa, John B Little, Takamitsu A Kato, Hung-Ying Shih, Xian-Jin Xie, Paul F Wilson, John R Brogan, Akihiro Kurimasa, David J Chen, Joel S Bedford, Benjamin P C Chen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3979685?pdf=render

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http://europepmc.org/articles/PMC3979685?pdf=render

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