Lactococcus lactis FNBPA+ (pValac:e6ag85a) Induces Cellular and Humoral Immune Responses After Oral Immunization of Mice

Lactococcus lactis FNBPA+ (pValac:e6ag85a) Induces Cellular and Humoral Immune Responses After Oral Immunization of Mice

The development of a new vaccine strategy against tuberculosis is urgently needed and has been greatly encouraged by the scientific community worldwide. In this work, we constructed a lactococcal DNA vaccine based on the fusion of two Mycobacterium tuberculosis antigens, ESAT-6 and Ag85A, and examin...

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Bibliographic Details
Main Authors: Camila Prósperi de Castro, Bianca Mendes Souza, Pamela Mancha-Agresti, Vanessa Bastos Pereira, Meritxell Zurita-Turk, Tatiane Melo Preisser, Vanessa Pecini da Cunha, Janete Soares Coelho dos Santos, Sophie Yvette Leclercq, Vasco Azevedo, Anderson Miyoshi
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Microbiology
Subjects:
lactic acid bacteria
Lactococcus lactis
DNA vaccine
tuberculosis
ESAT6/Ag85A
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2021.676172/full

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