Intrinsically Disordered Proteins as Regulators of Transient Biological Processes and as Untapped Drug Targets

Intrinsically Disordered Proteins as Regulators of Transient Biological Processes and as Untapped Drug Targets

Intrinsically disordered proteins (IDPs) are critical players in the dynamic control of diverse cellular processes, and provide potential new drug targets because their dysregulation is closely related to many diseases. This review focuses on several medicinal studies that have identified low-molecu...

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Main Authors: Yusuke Hosoya, Junko Ohkanda
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Molecules
Subjects:
intrinsically disordered proteins
protein–protein interactions
liquid–liquid phase separation
drug discovery
Online Access:https://www.mdpi.com/1420-3049/26/8/2118
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spelling doaj-c5cfe4608bbf4fde8f45e57b3d9785632021-04-07T23:04:02ZengMDPI AGMolecules1420-30492021-04-01262118211810.3390/molecules26082118Intrinsically Disordered Proteins as Regulators of Transient Biological Processes and as Untapped Drug TargetsYusuke Hosoya0Junko Ohkanda1Academic Assembly, Institute of Agriculture, Shinshu University, 8304 Minami-Minowa, Kami-Ina, Nagano 399-4598, JapanAcademic Assembly, Institute of Agriculture, Shinshu University, 8304 Minami-Minowa, Kami-Ina, Nagano 399-4598, JapanIntrinsically disordered proteins (IDPs) are critical players in the dynamic control of diverse cellular processes, and provide potential new drug targets because their dysregulation is closely related to many diseases. This review focuses on several medicinal studies that have identified low-molecular-weight inhibitors of IDPs. In addition, clinically relevant liquid–liquid phase separations—which critically involve both intermolecular interactions between IDPs and their posttranslational modification—are analyzed to understand the potential of IDPs as new drug targets.https://www.mdpi.com/1420-3049/26/8/2118intrinsically disordered proteinsprotein–protein interactionsliquid–liquid phase separationdrug discovery
collection DOAJ
language English
format Article
sources DOAJ
author Yusuke Hosoya
Junko Ohkanda
spellingShingle Yusuke Hosoya
Junko Ohkanda
Intrinsically Disordered Proteins as Regulators of Transient Biological Processes and as Untapped Drug Targets
Molecules
intrinsically disordered proteins
protein–protein interactions
liquid–liquid phase separation
drug discovery
author_facet Yusuke Hosoya
Junko Ohkanda
author_sort Yusuke Hosoya
title Intrinsically Disordered Proteins as Regulators of Transient Biological Processes and as Untapped Drug Targets
title_short Intrinsically Disordered Proteins as Regulators of Transient Biological Processes and as Untapped Drug Targets
title_full Intrinsically Disordered Proteins as Regulators of Transient Biological Processes and as Untapped Drug Targets
title_fullStr Intrinsically Disordered Proteins as Regulators of Transient Biological Processes and as Untapped Drug Targets
title_full_unstemmed Intrinsically Disordered Proteins as Regulators of Transient Biological Processes and as Untapped Drug Targets
title_sort intrinsically disordered proteins as regulators of transient biological processes and as untapped drug targets
publisher MDPI AG
series Molecules
issn 1420-3049
publishDate 2021-04-01
description Intrinsically disordered proteins (IDPs) are critical players in the dynamic control of diverse cellular processes, and provide potential new drug targets because their dysregulation is closely related to many diseases. This review focuses on several medicinal studies that have identified low-molecular-weight inhibitors of IDPs. In addition, clinically relevant liquid–liquid phase separations—which critically involve both intermolecular interactions between IDPs and their posttranslational modification—are analyzed to understand the potential of IDPs as new drug targets.
topic intrinsically disordered proteins
protein–protein interactions
liquid–liquid phase separation
drug discovery
url https://www.mdpi.com/1420-3049/26/8/2118
work_keys_str_mv AT yusukehosoya intrinsicallydisorderedproteinsasregulatorsoftransientbiologicalprocessesandasuntappeddrugtargets
AT junkoohkanda intrinsicallydisorderedproteinsasregulatorsoftransientbiologicalprocessesandasuntappeddrugtargets
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