Tanycytes control the hormonal output of the hypothalamic-pituitary-thyroid axis

The hypothalamic-pituitary-thyroid (HPT) axis regulates a wide range of physiological processes. Here the authors show that hypothalamic tanycytes play a role in the homeostatic regulation of the HPT axis; activation of TRH signaling in tanycytes elevates their intracellular Ca2+ via Gαq/11 pathway,...

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Main Authors:	Helge Müller-Fielitz, Marcus Stahr, Mareike Bernau, Marius Richter, Sebastian Abele, Victor Krajka, Anika Benzin, Jan Wenzel, Kathrin Kalies, Jens Mittag, Heike Heuer, Stefan Offermanns, Markus Schwaninger
Format:	Article
Language:	English
Published:	Nature Publishing Group 2017-09-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-017-00604-6

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spelling	doaj-c5cc71a5e3d64ec38fd693c1f9663f552021-05-11T07:18:20ZengNature Publishing GroupNature Communications2041-17232017-09-018111310.1038/s41467-017-00604-6Tanycytes control the hormonal output of the hypothalamic-pituitary-thyroid axisHelge Müller-Fielitz0Marcus Stahr1Mareike Bernau2Marius Richter3Sebastian Abele4Victor Krajka5Anika Benzin6Jan Wenzel7Kathrin Kalies8Jens Mittag9Heike Heuer10Stefan Offermanns11Markus Schwaninger12Institute for Experimental and Clinical Pharmacology and Toxicology, University of LübeckInstitute for Experimental and Clinical Pharmacology and Toxicology, University of LübeckInstitute for Experimental and Clinical Pharmacology and Toxicology, University of LübeckInstitute for Experimental and Clinical Pharmacology and Toxicology, University of LübeckInstitute for Experimental and Clinical Pharmacology and Toxicology, University of LübeckInstitute for Experimental and Clinical Pharmacology and Toxicology, University of LübeckInstitute for Experimental and Clinical Pharmacology and Toxicology, University of LübeckInstitute for Experimental and Clinical Pharmacology and Toxicology, University of LübeckInstitute of Anatomy, University of LübeckDepartment of Internal Medicine, Molecular Endocrinology, University of LübeckLeibniz Research Institute for Environmental MedicineDepartment of Pharmacology, Max-Planck-Institute for Heart and Lung ResearchInstitute for Experimental and Clinical Pharmacology and Toxicology, University of LübeckThe hypothalamic-pituitary-thyroid (HPT) axis regulates a wide range of physiological processes. Here the authors show that hypothalamic tanycytes play a role in the homeostatic regulation of the HPT axis; activation of TRH signaling in tanycytes elevates their intracellular Ca2+ via Gαq/11 pathway, ultimately resulting in reduced TRH release into the pituitary vessels.https://doi.org/10.1038/s41467-017-00604-6
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Helge Müller-Fielitz Marcus Stahr Mareike Bernau Marius Richter Sebastian Abele Victor Krajka Anika Benzin Jan Wenzel Kathrin Kalies Jens Mittag Heike Heuer Stefan Offermanns Markus Schwaninger
spellingShingle	Helge Müller-Fielitz Marcus Stahr Mareike Bernau Marius Richter Sebastian Abele Victor Krajka Anika Benzin Jan Wenzel Kathrin Kalies Jens Mittag Heike Heuer Stefan Offermanns Markus Schwaninger Tanycytes control the hormonal output of the hypothalamic-pituitary-thyroid axis Nature Communications
author_facet	Helge Müller-Fielitz Marcus Stahr Mareike Bernau Marius Richter Sebastian Abele Victor Krajka Anika Benzin Jan Wenzel Kathrin Kalies Jens Mittag Heike Heuer Stefan Offermanns Markus Schwaninger
author_sort	Helge Müller-Fielitz
title	Tanycytes control the hormonal output of the hypothalamic-pituitary-thyroid axis
title_short	Tanycytes control the hormonal output of the hypothalamic-pituitary-thyroid axis
title_full	Tanycytes control the hormonal output of the hypothalamic-pituitary-thyroid axis
title_fullStr	Tanycytes control the hormonal output of the hypothalamic-pituitary-thyroid axis
title_full_unstemmed	Tanycytes control the hormonal output of the hypothalamic-pituitary-thyroid axis
title_sort	tanycytes control the hormonal output of the hypothalamic-pituitary-thyroid axis
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2017-09-01
description	The hypothalamic-pituitary-thyroid (HPT) axis regulates a wide range of physiological processes. Here the authors show that hypothalamic tanycytes play a role in the homeostatic regulation of the HPT axis; activation of TRH signaling in tanycytes elevates their intracellular Ca2+ via Gαq/11 pathway, ultimately resulting in reduced TRH release into the pituitary vessels.
url	https://doi.org/10.1038/s41467-017-00604-6
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Tanycytes control the hormonal output of the hypothalamic-pituitary-thyroid axis

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