Germinal center B cell development has distinctly regulated stages completed by disengagement from T cell help

Germinal center B cell development has distinctly regulated stages completed by disengagement from T cell help

To reconcile conflicting reports on the role of CD40 signaling in germinal center (GC) formation, we examined the earliest stages of murine GC B cell differentiation. Peri-follicular GC precursors first expressed intermediate levels of BCL6 while co-expressing the transcription factors RelB and IRF4...

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Bibliographic Details
Main Authors: Ting-ting Zhang, David G Gonzalez, Christine M Cote, Steven M Kerfoot, Shaoli Deng, Yuqing Cheng, Masaki Magari, Ann M Haberman
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-05-01
Series:eLife
Subjects:
germinal center
GC precursor
transcription factor
CD40
plasmablast
T cell help
Online Access:https://elifesciences.org/articles/19552

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