Dendritic cell-derived exosomes promote natural killer cell activation and proliferation: a role for NKG2D ligands and IL-15Ralpha.

Dendritic cell-derived exosomes promote natural killer cell activation and proliferation: a role for NKG2D ligands and IL-15Ralpha.

Dendritic cell (DC) derived-exosomes (Dex) are nanomeric vesicles harboring functional MHC/peptide complexes promoting T cell-dependent tumor rejection. In the first Phase I trial using peptide-pulsed Dex, the observation of clinical regressions in the absence of T cell responses prompted the search...

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Bibliographic Details
Main Authors: Sophie Viaud, Magali Terme, Caroline Flament, Julien Taieb, Fabrice André, Sophie Novault, Bernard Escudier, Caroline Robert, Sophie Caillat-Zucman, Thomas Tursz, Laurence Zitvogel, Nathalie Chaput
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2657211?pdf=render

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