Diagnostic capability of Pulsar perimetry in pre-perimetric and early glaucoma

Abstract This study aimed to compare the diagnostic capability of Pulsar perimetry (Pulsar) in pre-perimetric glaucoma (PPG) and early glaucoma (EG) with that of Flicker perimetry (Flicker) and spectral-domain optical conference tomography (SD-OCT). This prospective cross-sectional study included 25...

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Main Authors: Kazunori Hirasawa, Natsumi Takahashi, Kazuhiro Matsumura, Masayuki Kasahara, Nobuyuki Shoji
Format: Article
Language:English
Published: Nature Publishing Group 2017-06-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-03550-x
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spelling doaj-c59dbea343784d34945990e395cf59192020-12-08T02:50:58ZengNature Publishing GroupScientific Reports2045-23222017-06-017111110.1038/s41598-017-03550-xDiagnostic capability of Pulsar perimetry in pre-perimetric and early glaucomaKazunori Hirasawa0Natsumi Takahashi1Kazuhiro Matsumura2Masayuki Kasahara3Nobuyuki Shoji4Department of Orthoptics and Visual Science, School of Allied Health Sciences, Kitasato UniversityDepartment of Ophthalmology, Kitasato University HospitalDepartment of Ophthalmology, School of Medicine, Kitasato UniversityDepartment of Ophthalmology, School of Medicine, Kitasato UniversityDepartment of Ophthalmology, School of Medicine, Kitasato UniversityAbstract This study aimed to compare the diagnostic capability of Pulsar perimetry (Pulsar) in pre-perimetric glaucoma (PPG) and early glaucoma (EG) with that of Flicker perimetry (Flicker) and spectral-domain optical conference tomography (SD-OCT). This prospective cross-sectional study included 25 eyes of 25 PPG patients, 35 eyes of 35 EG patients, and 42 eyes of 42 healthy participants. The diagnostic capability using the area under the curve (AUC) of the best parameter and agreement of detectability between structural and functional measurements were compared. For PPG patients, the AUC of Pulsar, Flicker, OCT-disc, and OCT-macular was 0.733, 0.663, 0.842, and 0.780, respectively. The AUC of Flicker was significantly lower than that of OCT-disc (p = 0.016). For EG patients, the AUC of Pulsar, Flicker, OCT-disc, and OCT-macular were 0.851, 0.869, 0.907, and 0.861, respectively. There was no significant difference in AUC among these methods. The agreement between structural and functional measurements expressed by kappa value ranged from −0.16 to 0.07 for PPG and from 0.01 to 0.25 for EG. Although the diagnostic capability of Pulsar in the PPG and EG groups was equal to that of Flicker and SD-OCT, the agreements between structural and functional measurements for both PPG and EG were poor.https://doi.org/10.1038/s41598-017-03550-x
collection DOAJ
language English
format Article
sources DOAJ
author Kazunori Hirasawa
Natsumi Takahashi
Kazuhiro Matsumura
Masayuki Kasahara
Nobuyuki Shoji
spellingShingle Kazunori Hirasawa
Natsumi Takahashi
Kazuhiro Matsumura
Masayuki Kasahara
Nobuyuki Shoji
Diagnostic capability of Pulsar perimetry in pre-perimetric and early glaucoma
Scientific Reports
author_facet Kazunori Hirasawa
Natsumi Takahashi
Kazuhiro Matsumura
Masayuki Kasahara
Nobuyuki Shoji
author_sort Kazunori Hirasawa
title Diagnostic capability of Pulsar perimetry in pre-perimetric and early glaucoma
title_short Diagnostic capability of Pulsar perimetry in pre-perimetric and early glaucoma
title_full Diagnostic capability of Pulsar perimetry in pre-perimetric and early glaucoma
title_fullStr Diagnostic capability of Pulsar perimetry in pre-perimetric and early glaucoma
title_full_unstemmed Diagnostic capability of Pulsar perimetry in pre-perimetric and early glaucoma
title_sort diagnostic capability of pulsar perimetry in pre-perimetric and early glaucoma
publisher Nature Publishing Group
series Scientific Reports
issn 2045-2322
publishDate 2017-06-01
description Abstract This study aimed to compare the diagnostic capability of Pulsar perimetry (Pulsar) in pre-perimetric glaucoma (PPG) and early glaucoma (EG) with that of Flicker perimetry (Flicker) and spectral-domain optical conference tomography (SD-OCT). This prospective cross-sectional study included 25 eyes of 25 PPG patients, 35 eyes of 35 EG patients, and 42 eyes of 42 healthy participants. The diagnostic capability using the area under the curve (AUC) of the best parameter and agreement of detectability between structural and functional measurements were compared. For PPG patients, the AUC of Pulsar, Flicker, OCT-disc, and OCT-macular was 0.733, 0.663, 0.842, and 0.780, respectively. The AUC of Flicker was significantly lower than that of OCT-disc (p = 0.016). For EG patients, the AUC of Pulsar, Flicker, OCT-disc, and OCT-macular were 0.851, 0.869, 0.907, and 0.861, respectively. There was no significant difference in AUC among these methods. The agreement between structural and functional measurements expressed by kappa value ranged from −0.16 to 0.07 for PPG and from 0.01 to 0.25 for EG. Although the diagnostic capability of Pulsar in the PPG and EG groups was equal to that of Flicker and SD-OCT, the agreements between structural and functional measurements for both PPG and EG were poor.
url https://doi.org/10.1038/s41598-017-03550-x
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