In Silico Exploration of Aryl Halides Analogues as CheckpointKinase 1 Inhibitors by Using 3D QSAR, Molecular Docking Study,and ADMET Screening

In Silico Exploration of Aryl Halides Analogues as CheckpointKinase 1 Inhibitors by Using 3D QSAR, Molecular Docking Study,and ADMET Screening

Purpose: In this review, a set of aryl halides analogs were identified as potent checkpoint kinase1 (Chk1) inhibitors through a series of computer-aided drug design processes, to develop modelswith good predictive ability, highlight the important interactions between the ligand and theChk1 receptor...

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Bibliographic Details
Main Authors: Adib Ghaleb, Adnane Aouidate, Mohammed Bouachrine, Tahar Lakhlifi, Abdelouhid Sbai
Format: Article
Language:English
Published: Tabriz University of Medical Sciences 2019-02-01
Series:Advanced Pharmaceutical Bulletin
Subjects:
3D-QSAR
Molecular-docking
In silico ADMET
Chk1 inhibitors
Aryl halides
Online Access:https://apb.tbzmed.ac.ir/PDF/apb-19609

Internet

https://apb.tbzmed.ac.ir/PDF/apb-19609

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