Spindle cell carcinoma of the breast as complex cystic lesion: a case report

• Main Authors: Masahiro Kitada, Satoshi Hayashi, Yoshinari Matsuda, Kei Ishibashi, Keisuke Oikawa, Naoyuki Miyokawa
• Format: Article
• Language: English
• Published: China Anti-Cancer Association 2014-06-01
• Series: Cancer Biology & Medicine
• Subjects: Breast cancer; spindle cell carcinoma; cystic lesion
• Online Access: http://www.cancerbiomed.org/index.php/cocr/article/view/645

Spindle cell carcinoma of the breast is a rare tumor. This tumor can proliferate rapidly and cause cystic changes because of internal tissue necrosis. We evaluated a 54-year-old woman with right breast lump. Mammography showed a category four mass with a diameter of 2.5 cm. Ultrasonography (US) revealed a complex cystic lesion, and fine-needle aspiration (FNA) cytology demonstrated bloody fluid and malignant cells. Partial breast resection and sentinel lymph node biopsy were performed. Immunohistology revealed spindle cells with positive results for cytokeratin (AE1/AE3) and vimentin, partially positive results for s-100, and negative results for desmin and α-actin. The pathological stage was ⅡA, and biochemical characterization showed that the tumor was triple negative. Six courses of FEC-100 chemotherapy (5-fluorouracil 500 mg/m², epirubicin 100 mg/m², and cyclophosphamide 500 mg/m²) were administered. Radiotherapy was performed. This case is discussed with reference to the literature.