Comparable Initial Engagement of Intracellular Signaling Pathways by Parathyroid Hormone Receptor Ligands Teriparatide, Abaloparatide, and Long‐Acting PTH

Comparable Initial Engagement of Intracellular Signaling Pathways by Parathyroid Hormone Receptor Ligands Teriparatide, Abaloparatide, and Long‐Acting PTH

ABSTRACT Multiple analogs of parathyroid hormone, all of which bind to the PTH/PTHrP receptor PTH1R, are used for patients with osteoporosis and hypoparathyroidism. Although ligands such as abaloparatide, teriparatide (hPTH 1‐34 [TPTD]), and long‐acting PTH (LA‐PTH) show distinct biologic effects wi...

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Bibliographic Details
Main Authors: Tadatoshi Sato, Shiv Verma, Ashok Khatri, Thomas Dean, Olga Goransson, Thomas J Gardella, Marc N Wein
Format: Article
Language:English
Published: Wiley 2021-05-01
Series:JBMR Plus
Subjects:
MOLECULAR PATHWAYS
REMODELING
BONE MODELING AND REMODELING
PTH/Vit D/FGF23
CELL/TISSUE SIGNALING
ENDOCRINE PATHWAYS
Online Access:https://doi.org/10.1002/jbm4.10441

Internet

https://doi.org/10.1002/jbm4.10441

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