MiR-34a inhibitor protects mesenchymal stem cells from hyperglycaemic injury through the activation of the SIRT1/FoxO3a autophagy pathway

MiR-34a inhibitor protects mesenchymal stem cells from hyperglycaemic injury through the activation of the SIRT1/FoxO3a autophagy pathway

Abstract Background Mesenchymal stem cells (MSCs) are favourable treatments for ischaemic diseases; however, MSCs from diabetic patients are not useful for this purpose. Recent studies have shown that the expression of miR-34a is significantly increased in patients with hyperglycaemia; the precise r...

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Bibliographic Details
Main Authors: Fengyun Zhang, Fei Gao, Kun Wang, Xiaohong Liu, Zhuoqi Zhang
Format: Article
Language:English
Published: BMC 2021-02-01
Series:Stem Cell Research & Therapy
Subjects:
Microrna-34a
Mesenchymal stem cells
Hyperglycaemia
Senescence
Autophagy
Online Access:https://doi.org/10.1186/s13287-021-02183-2

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