Clinical importance of CD7 expression in acute myelocytic leukemia (AML)

• Main Authors: Toogheh G, Sadredini M, Keihani M, Sharifian R, Sefati R
• Format: Article
• Language: fas
• Published: Tehran University of Medical Sciences 2001-09-01
• Series: Tehran University Medical Journal
• Online Access: http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/5568.pdf&manuscript_id=5568

Many studies have shown the clinical importance of CD7 expression in AML patients. To evaluate the clinical importance and response to chemotherapy in CD7 positive AML, this study was conducted. From the patients, 76 cases were studied during 3 years. In 3 years of this study 70.5 percent of CD7 positive and 89.6 percent of CD7 negative patients achieved complete remission with no significant difference between these two groups (P=0.11). We concluded that despite no importance of expression of this antigen in our patients, prevalence of CD7 positive cases in our study in higher than similar studies done abroad (52.6 percent versus 30 percent). It seems in respect of small number of our patients for evaluation of clinical and laboratory properties, larger study is needed.