Severe airway epithelial injury, aberrant repair and bronchiolitis obliterans develops after diacetyl instillation in rats.

Bronchiolitis obliterans (BO) is a fibrotic lung disease that occurs in a variety of clinical settings, including toxin exposures, autoimmunity and lung or bone marrow transplant. Despite its increasing clinical importance, little is known regarding the underlying disease mechanisms due to a lack of...

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Bibliographic Details
Main Authors: Scott M Palmer, Gordon P Flake, Fran L Kelly, Helen L Zhang, Julia L Nugent, Patrick J Kirby, Julie F Foley, William M Gwinn, Dan L Morgan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-03-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3064568?pdf=render