Synthesis, Structural and Thermal Studies of 3-(1-Benzyl-1,2,3,6-tetrahydropyridin-4-yl)-5-ethoxy-1H-indole (D2AAK1_3) as Dopamine D2 Receptor Ligand

Synthesis, Structural and Thermal Studies of 3-(1-Benzyl-1,2,3,6-tetrahydropyridin-4-yl)-5-ethoxy-1H-indole (D2AAK1_3) as Dopamine D2 Receptor Ligand

Compound D2AAK1_3 was designed as a modification of the lead structure D2AAK1 (an in vivo active multi-target compound with nanomolar affinity to a number of aminergic GPCRs) and synthesized in the reaction of 5-ethoxyindole and 1-benzyl-4-piperidone. This compound has an affinity to the human dopam...

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Bibliographic Details
Main Authors: Magda Kondej, Agata Bartyzel, Monika Pitucha, Tomasz M. Wróbel, Andrea G. Silva, Dariusz Matosiuk, Marián Castro, Agnieszka A. Kaczor
Format: Article
Language:English
Published: MDPI AG 2018-09-01
Series:Molecules
Subjects:
dopamine D2 receptor
dopamine D2 receptor antagonist
molecular modeling
thermal studies
X-ray studies
Online Access:http://www.mdpi.com/1420-3049/23/9/2249

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