Discovery of New Inhibitors of Transforming Growth Factor-Beta Type 1 Receptor by Utilizing Docking and Structure-Activity Relationship Analysis

Discovery of New Inhibitors of Transforming Growth Factor-Beta Type 1 Receptor by Utilizing Docking and Structure-Activity Relationship Analysis

The transforming growth factor-beta (TGF-β) plays an important role in pathological fibrosis and cancer transformation. Therefore, the inhibition of the TGF-β signaling pathway has therapeutic potential in the treatment of cancer. In this study, the binding modes between 47 molecul...

Full description

Bibliographic Details
Main Authors: Jun-Hao Jiang, Ping Deng
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:International Journal of Molecular Sciences
Subjects:
TGF-beta
docking
structure-activity relationship
inhibitors
discovery studio
TGF-β
TβR1
Online Access:https://www.mdpi.com/1422-0067/20/17/4090

Internet

https://www.mdpi.com/1422-0067/20/17/4090

Similar Items