Optogenetic excitation of cholinergic inputs to hippocampus primes future contextual fear associations

Abstract Learning about context is essential for appropriate behavioral strategies, but important contingencies may not arise during initial learning. A variant of contextual fear conditioning, context pre-exposure facilitation, allows us to directly test the relationship between novelty-induced ace...

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Main Authors:	Sarah Hersman, Jesse Cushman, Noah Lemelson, Kate Wassum, Shahrdad Lotfipour, Michael S. Fanselow
Format:	Article
Language:	English
Published:	Nature Publishing Group 2017-05-01
Series:	Scientific Reports
Online Access:	https://doi.org/10.1038/s41598-017-02542-1

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spelling	doaj-c57996a3fc624abba2c492e3c3a6b4c92020-12-08T02:38:27ZengNature Publishing GroupScientific Reports2045-23222017-05-01711610.1038/s41598-017-02542-1Optogenetic excitation of cholinergic inputs to hippocampus primes future contextual fear associationsSarah Hersman0Jesse Cushman1Noah Lemelson2Kate Wassum3Shahrdad Lotfipour4Michael S. Fanselow5Department of Psychology and Psychiatry, University of California, Los AngelesDepartment of Psychology and Psychiatry, University of California, Los AngelesDepartment of Psychology and Psychiatry, University of California, Los AngelesDepartment of Psychology and Psychiatry, University of California, Los AngelesDepartment of Psychology and Psychiatry, University of California, Los AngelesDepartment of Psychology and Psychiatry, University of California, Los AngelesAbstract Learning about context is essential for appropriate behavioral strategies, but important contingencies may not arise during initial learning. A variant of contextual fear conditioning, context pre-exposure facilitation, allows us to directly test the relationship between novelty-induced acetylcholine release and later contextual associability. We demonstrate that optogenetically-enhanced acetylcholine during initial contextual exploration leads to stronger fear after subsequent pairing with shock, suggesting that novelty-induced acetylcholine release primes future contextual associations.https://doi.org/10.1038/s41598-017-02542-1
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Sarah Hersman Jesse Cushman Noah Lemelson Kate Wassum Shahrdad Lotfipour Michael S. Fanselow
spellingShingle	Sarah Hersman Jesse Cushman Noah Lemelson Kate Wassum Shahrdad Lotfipour Michael S. Fanselow Optogenetic excitation of cholinergic inputs to hippocampus primes future contextual fear associations Scientific Reports
author_facet	Sarah Hersman Jesse Cushman Noah Lemelson Kate Wassum Shahrdad Lotfipour Michael S. Fanselow
author_sort	Sarah Hersman
title	Optogenetic excitation of cholinergic inputs to hippocampus primes future contextual fear associations
title_short	Optogenetic excitation of cholinergic inputs to hippocampus primes future contextual fear associations
title_full	Optogenetic excitation of cholinergic inputs to hippocampus primes future contextual fear associations
title_fullStr	Optogenetic excitation of cholinergic inputs to hippocampus primes future contextual fear associations
title_full_unstemmed	Optogenetic excitation of cholinergic inputs to hippocampus primes future contextual fear associations
title_sort	optogenetic excitation of cholinergic inputs to hippocampus primes future contextual fear associations
publisher	Nature Publishing Group
series	Scientific Reports
issn	2045-2322
publishDate	2017-05-01
description	Abstract Learning about context is essential for appropriate behavioral strategies, but important contingencies may not arise during initial learning. A variant of contextual fear conditioning, context pre-exposure facilitation, allows us to directly test the relationship between novelty-induced acetylcholine release and later contextual associability. We demonstrate that optogenetically-enhanced acetylcholine during initial contextual exploration leads to stronger fear after subsequent pairing with shock, suggesting that novelty-induced acetylcholine release primes future contextual associations.
url	https://doi.org/10.1038/s41598-017-02542-1
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Optogenetic excitation of cholinergic inputs to hippocampus primes future contextual fear associations

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