Inhibition of Scavenger Receptor Class B Type 1 (SR-B1) Expression and Activity as a Potential Novel Target to Disrupt Cholesterol Availability in Castration-Resistant Prostate Cancer

Inhibition of Scavenger Receptor Class B Type 1 (SR-B1) Expression and Activity as a Potential Novel Target to Disrupt Cholesterol Availability in Castration-Resistant Prostate Cancer

There have been several studies that have linked elevated scavenger receptor class b type 1 (SR-B1) expression and activity to the development and progression of castration-resistant prostate cancer (CRPC). SR-B1 facilitates the influx of cholesterol to the cell from lipoproteins in systemic circula...

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Bibliographic Details
Main Authors: Mitali Pandey, Grace Cuddihy, Jacob A. Gordon, Michael E. Cox, Kishor M. Wasan
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Pharmaceutics
Subjects:
prostate cancer
castration-resistant prostate cancer
cholesterol uptake
scavenger receptor Class B type I high-density lipoproteins
patient survival
Online Access:https://www.mdpi.com/1999-4923/13/9/1509

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