ATM Regulated PTEN Degradation Is XIAP E3 Ubiquitin Ligase Mediated in p85α Deficient Cancer Cells and Influence Platinum Sensitivity

ATM Regulated PTEN Degradation Is XIAP E3 Ubiquitin Ligase Mediated in p85α Deficient Cancer Cells and Influence Platinum Sensitivity

Ataxia-telegiectasia mutated (ATM), phosphatase and tensin homolog (PTEN), and p85α are key tumour suppressors. Whether ATM regulates PTEN expression and influence platinum sensitivity is unknown. We generated ATM knockdowns (KD) and CRISPR knock outs (KO) in glioblastoma (LN18, LN229) and...

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Bibliographic Details
Main Authors: Reem Ali, Muslim Alabdullah, Islam Miligy, Makhliyo Normatova, Roya Babaei-Jadidi, Abdolrahman S. Nateri, Emad A. Rakha, Srinivasan Madhusudan
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:Cells
Subjects:
atm
pten
ck2α
p85α
xiap
cisplatin
ovarian cancers
Online Access:https://www.mdpi.com/2073-4409/8/10/1271

Internet

https://www.mdpi.com/2073-4409/8/10/1271

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