Structural Insight Into Conformational Changes Induced by ATP Binding in a Type III Secretion-Associated ATPase From Shigella flexneri

Structural Insight Into Conformational Changes Induced by ATP Binding in a Type III Secretion-Associated ATPase From Shigella flexneri

Gram-negative bacteria utilize the type III secretion system (T3SS) to inject effector proteins into the host cell cytoplasm, where they subvert cellular functions and assist pathogen invasion. The conserved type III-associated ATPase is critical for the separation of chaperones from effector protei...

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Bibliographic Details
Main Authors: Xiaopan Gao, Zhixia Mu, Xia Yu, Bo Qin, Justyna Wojdyla, Meitian Wang, Sheng Cui
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Microbiology
Subjects:
Shigella flexneri
T3SS
type III secretion-associated ATPase
F/V-type ATPase
proton motive force (PMF)
ATP analog
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2018.01468/full

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