The Caenorhabditis elegans homolog of Gen1/Yen1 resolvases links DNA damage signaling to DNA double-strand break repair.

The Caenorhabditis elegans homolog of Gen1/Yen1 resolvases links DNA damage signaling to DNA double-strand break repair.

DNA double-strand breaks (DSBs) can be repaired by homologous recombination (HR), which can involve Holliday junction (HJ) intermediates that are ultimately resolved by nucleolytic enzymes. An N-terminal fragment of human GEN1 has recently been shown to act as a Holliday junction resolvase, but litt...

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Bibliographic Details
Main Authors: Aymeric P Bailly, Alasdair Freeman, Julie Hall, Anne-Cécile Déclais, Arno Alpi, David M J Lilley, Shawn Ahmed, Anton Gartner
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-07-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC2908289?pdf=render

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