Acetaldehyde-Mediated Neurotoxicity: Relevance to Fetal Alcohol Spectrum Disorders

Acetaldehyde-Mediated Neurotoxicity: Relevance to Fetal Alcohol Spectrum Disorders

Ethanol-induced neuro-developmental abnormalities are associated with impaired insulin and IGF signaling, and increased oxidative stress in CNS neurons. We examined the roles of ethanol and its principal toxic metabolite, acetaldehyde, as mediators of impaired insulin/IGF signaling and oxidative inj...

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Bibliographic Details
Main Authors:	Ming Tong, Lisa Longato, Quynh-GiaoLy Nguyen, William C. Chen, Amy Spaisman, Suzanne M. de la Monte
Format:	Article
Language:	English
Published:	Hindawi Limited 2011-01-01
Series:	Oxidative Medicine and Cellular Longevity
Online Access:	http://dx.doi.org/10.1155/2011/213286

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