Murine interfollicular epidermal differentiation is gradualistic with GRHL3 controlling progression from stem to transition cell states

Murine interfollicular epidermal differentiation is gradualistic with GRHL3 controlling progression from stem to transition cell states

The interfollicular epidermis (IFE) is part of the epidermis but how it forms is unclear. Here, the authors perform scRNA sequencing at various developmental stages on the mouse epidermis and on deletion of Grhl3, showing IFE differentiation is gradual and that Grhl3 is needed for commitment to diff...

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Main Authors: Ziguang Lin, Suoqin Jin, Jefferson Chen, Zhuorui Li, Zhongqi Lin, Li Tang, Qing Nie, Bogi Andersen
Format: Article
Language:English
Published: Nature Publishing Group 2020-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-19234-6
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spelling doaj-c5557fca52a74da19ba8e850221bae6e2021-05-11T08:18:03ZengNature Publishing GroupNature Communications2041-17232020-10-0111111510.1038/s41467-020-19234-6Murine interfollicular epidermal differentiation is gradualistic with GRHL3 controlling progression from stem to transition cell statesZiguang Lin0Suoqin Jin1Jefferson Chen2Zhuorui Li3Zhongqi Lin4Li Tang5Qing Nie6Bogi Andersen7Department of Biological Chemistry, School of Medicine, University of CaliforniaDepartment of Mathematics, University of CaliforniaDepartment of Biological Chemistry, School of Medicine, University of CaliforniaDepartment of Biological Chemistry, School of Medicine, University of CaliforniaDepartment of Biological Chemistry, School of Medicine, University of CaliforniaDepartment of Biological Chemistry, School of Medicine, University of CaliforniaDepartment of Mathematics, University of CaliforniaDepartment of Biological Chemistry, School of Medicine, University of CaliforniaThe interfollicular epidermis (IFE) is part of the epidermis but how it forms is unclear. Here, the authors perform scRNA sequencing at various developmental stages on the mouse epidermis and on deletion of Grhl3, showing IFE differentiation is gradual and that Grhl3 is needed for commitment to differentiation by regulating Wnt signalling pathway.https://doi.org/10.1038/s41467-020-19234-6
collection DOAJ
language English
format Article
sources DOAJ
author Ziguang Lin
Suoqin Jin
Jefferson Chen
Zhuorui Li
Zhongqi Lin
Li Tang
Qing Nie
Bogi Andersen
spellingShingle Ziguang Lin
Suoqin Jin
Jefferson Chen
Zhuorui Li
Zhongqi Lin
Li Tang
Qing Nie
Bogi Andersen
Murine interfollicular epidermal differentiation is gradualistic with GRHL3 controlling progression from stem to transition cell states
Nature Communications
author_facet Ziguang Lin
Suoqin Jin
Jefferson Chen
Zhuorui Li
Zhongqi Lin
Li Tang
Qing Nie
Bogi Andersen
author_sort Ziguang Lin
title Murine interfollicular epidermal differentiation is gradualistic with GRHL3 controlling progression from stem to transition cell states
title_short Murine interfollicular epidermal differentiation is gradualistic with GRHL3 controlling progression from stem to transition cell states
title_full Murine interfollicular epidermal differentiation is gradualistic with GRHL3 controlling progression from stem to transition cell states
title_fullStr Murine interfollicular epidermal differentiation is gradualistic with GRHL3 controlling progression from stem to transition cell states
title_full_unstemmed Murine interfollicular epidermal differentiation is gradualistic with GRHL3 controlling progression from stem to transition cell states
title_sort murine interfollicular epidermal differentiation is gradualistic with grhl3 controlling progression from stem to transition cell states
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2020-10-01
description The interfollicular epidermis (IFE) is part of the epidermis but how it forms is unclear. Here, the authors perform scRNA sequencing at various developmental stages on the mouse epidermis and on deletion of Grhl3, showing IFE differentiation is gradual and that Grhl3 is needed for commitment to differentiation by regulating Wnt signalling pathway.
url https://doi.org/10.1038/s41467-020-19234-6
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AT suoqinjin murineinterfollicularepidermaldifferentiationisgradualisticwithgrhl3controllingprogressionfromstemtotransitioncellstates
AT jeffersonchen murineinterfollicularepidermaldifferentiationisgradualisticwithgrhl3controllingprogressionfromstemtotransitioncellstates
AT zhuoruili murineinterfollicularepidermaldifferentiationisgradualisticwithgrhl3controllingprogressionfromstemtotransitioncellstates
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AT bogiandersen murineinterfollicularepidermaldifferentiationisgradualisticwithgrhl3controllingprogressionfromstemtotransitioncellstates
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