Lentiviral vector transduction of spermatozoa as a tool for the study of early development

Lentiviral vector transduction of spermatozoa as a tool for the study of early development

Spermatozoa and lentiviruses are two of nature’s most efficient gene delivery vehicles. Both can be genetically modified and used independently for the generation of transgenic animals or gene transfer/therapy of inherited disorders. Here we show that mature spermatozoa can be directly transduced wi...

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Bibliographic Details
Main Authors: Anil Chandrashekran, Ihsan Isa, Jayesh Dudhia, Adrian J. Thrasher, Nicholas Dibb, Colin Casimir, Carol Readhead, Robert Winston
Format: Article
Language:English
Published: Wiley 2014-01-01
Series:FEBS Open Bio
Subjects:
Lentiviral vectors
Spermatozoa
Transduction
Development
Transgenics
In vitro fertilisation
Online Access:http://www.sciencedirect.com/science/article/pii/S2211546314000199

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