Constitutive overexpression of Norrin activates Wnt/β-catenin and endothelin-2 signaling to protect photoreceptors from light damage

Constitutive overexpression of Norrin activates Wnt/β-catenin and endothelin-2 signaling to protect photoreceptors from light damage

Norrin is a retinal signaling molecule which is expressed in Müller glia and binds to Frizzled-4 to activate canonical Wnt/β-catenin signaling. Norrin is part of an essential signaling system that controls the formation of retinal capillaries during development. To evaluate neuroprotective propertie...

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Bibliographic Details
Main Authors: Barbara M. Braunger, Andreas Ohlmann, Marcus Koch, Naoyuki Tanimoto, Cornelia Volz, Ying Yang, Michael R. Bösl, Ales Cvekl, Herbert Jägle, Mathias W. Seeliger, Ernst R. Tamm
Format: Article
Language:English
Published: Elsevier 2013-02-01
Series:Neurobiology of Disease
Subjects:
Endothelin receptor B
Glial fibrillary acidic protein
Brain-derived neurotrophic factor
PI3K-Akt
Retinal degeneration
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996112003221

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http://www.sciencedirect.com/science/article/pii/S0969996112003221

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