An amphipathic peptide with antibiotic activity against multidrug-resistant Gram-negative bacteria
Peptide antibiotics often display a very narrow therapeutic index. Here, the authors present an optimized peptide antibiotic with broad-spectrum in vitro activities, in vivo efficacy in multiple disease models against multidrug-resistant Gram-negative infections, and reduced toxicity.
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| Language: | English |
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Nature Publishing Group
2020-06-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-16950-x |
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doaj-c52da634b87d440cbbc0c10a3c254c562021-06-27T11:13:58ZengNature Publishing GroupNature Communications2041-17232020-06-0111111310.1038/s41467-020-16950-xAn amphipathic peptide with antibiotic activity against multidrug-resistant Gram-negative bacteriaAlysha G. Elliott0Johnny X. Huang1Søren Neve2Johannes Zuegg3Ingrid A. Edwards4Amy K. Cain5Christine J. Boinett6Lars Barquist7Carina Vingsbo Lundberg8Jason Steen9Mark S. Butler10Mehdi Mobli11Kaela M. Porter12Mark A. T. Blaskovich13Sergio Lociuro14Magnus Strandh15Matthew A. Cooper16Centre for Superbug Solutions, Institute for Molecular Bioscience, The University of QueenslandCentre for Superbug Solutions, Institute for Molecular Bioscience, The University of QueenslandOrphazymeCentre for Superbug Solutions, Institute for Molecular Bioscience, The University of QueenslandCentre for Superbug Solutions, Institute for Molecular Bioscience, The University of QueenslandWellcome Sanger InstituteWellcome Sanger InstituteHelmholtz Institute for RNA-based Infection Research (HIRI)Statens Serum InstitutSchool of Chemistry and Molecular Biosciences, The University of QueenslandCentre for Superbug Solutions, Institute for Molecular Bioscience, The University of QueenslandCentre for Advanced Imaging, The University of QueenslandAdenium Biotech ApSCentre for Superbug Solutions, Institute for Molecular Bioscience, The University of QueenslandBioVersys AGAdenium Biotech ApSCentre for Superbug Solutions, Institute for Molecular Bioscience, The University of QueenslandPeptide antibiotics often display a very narrow therapeutic index. Here, the authors present an optimized peptide antibiotic with broad-spectrum in vitro activities, in vivo efficacy in multiple disease models against multidrug-resistant Gram-negative infections, and reduced toxicity.https://doi.org/10.1038/s41467-020-16950-x |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Alysha G. Elliott Johnny X. Huang Søren Neve Johannes Zuegg Ingrid A. Edwards Amy K. Cain Christine J. Boinett Lars Barquist Carina Vingsbo Lundberg Jason Steen Mark S. Butler Mehdi Mobli Kaela M. Porter Mark A. T. Blaskovich Sergio Lociuro Magnus Strandh Matthew A. Cooper |
| spellingShingle |
Alysha G. Elliott Johnny X. Huang Søren Neve Johannes Zuegg Ingrid A. Edwards Amy K. Cain Christine J. Boinett Lars Barquist Carina Vingsbo Lundberg Jason Steen Mark S. Butler Mehdi Mobli Kaela M. Porter Mark A. T. Blaskovich Sergio Lociuro Magnus Strandh Matthew A. Cooper An amphipathic peptide with antibiotic activity against multidrug-resistant Gram-negative bacteria Nature Communications |
| author_facet |
Alysha G. Elliott Johnny X. Huang Søren Neve Johannes Zuegg Ingrid A. Edwards Amy K. Cain Christine J. Boinett Lars Barquist Carina Vingsbo Lundberg Jason Steen Mark S. Butler Mehdi Mobli Kaela M. Porter Mark A. T. Blaskovich Sergio Lociuro Magnus Strandh Matthew A. Cooper |
| author_sort |
Alysha G. Elliott |
| title |
An amphipathic peptide with antibiotic activity against multidrug-resistant Gram-negative bacteria |
| title_short |
An amphipathic peptide with antibiotic activity against multidrug-resistant Gram-negative bacteria |
| title_full |
An amphipathic peptide with antibiotic activity against multidrug-resistant Gram-negative bacteria |
| title_fullStr |
An amphipathic peptide with antibiotic activity against multidrug-resistant Gram-negative bacteria |
| title_full_unstemmed |
An amphipathic peptide with antibiotic activity against multidrug-resistant Gram-negative bacteria |
| title_sort |
amphipathic peptide with antibiotic activity against multidrug-resistant gram-negative bacteria |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2020-06-01 |
| description |
Peptide antibiotics often display a very narrow therapeutic index. Here, the authors present an optimized peptide antibiotic with broad-spectrum in vitro activities, in vivo efficacy in multiple disease models against multidrug-resistant Gram-negative infections, and reduced toxicity. |
| url |
https://doi.org/10.1038/s41467-020-16950-x |
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