The haematological and biochemical profile of the tumor-bearing rats submited to the cytostatic treatment with some polyphenolic or polysaccharidic biopreparations
The assessment of the biocompatibility between the development of the tumor-bearing animal’s physiological processes and the polysaccharidic or polyphenolic antitumoral treatment was performed in vivo, on experimental models adequate to the preclinical pharmacotoxicological research. The slight decr...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
"Alexandru Ioan Cuza" University of Iași
2009-03-01
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| Series: | Analele Ştiinţifice Ale Universităţii Alexandru Ioan Cuza din Iași,Sectiunea II A : Genetica si Biologie Moleculara |
| Online Access: | http://www.gbm.bio.uaic.ro/index.php/gbm/article/view/453 |
| Summary: | The assessment of the biocompatibility between the development of the tumor-bearing animal’s
physiological processes and the polysaccharidic or polyphenolic antitumoral treatment was performed in vivo, on
experimental models adequate to the preclinical pharmacotoxicological research. The slight decrease of the total number
of circulatory erythrocytes, – correlated, by sense and amplitude, to the levels of the hemoglobin and hematocrit – the low
level of leukocytosis and trombocytosis or thrombocytopenia, have reflected a moderate impact of the polysaccharidic or
polyphenolic extracts upon the hemo- , leuko-, and thrombopoetic organs. The plasmatic hypoproteinemia,
hypoalbuminemia, hyperglobulinemia, moderate hypoglycemia, hypo- or hyperlactacidemia, minor hyperlipemia,
hypocholesterolemia and the slight increases or decreases of the plasmatic free fatty acids levels - biochemical variations
registered in our experimental conditions - suggest the interference of the bioactive agents with the tissular metabolic
processes, which is materialized through modifications of some plasmatic biochemical parameters, which are
circumscribable in the normal limits and not in the pathological ones. The bulk of results proves the moderate toxicity of
the polysaccharidic and polyphenolic biopreparations upon the normal cells of the animal organism and, especially, upon
the organs directly involved in maintaining the internal medium homeostasis. |
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| ISSN: | 1582-3571 2248-3276 |