Benzylidene-bis-(4-Hydroxycoumarin) and Benzopyrano-Coumarin Derivatives: Synthesis, 1H/13C-NMR Conformational and X-ray Crystal Structure Studies and In Vitro Antiviral Activity Evaluations

Benzylidene-bis-(4-Hydroxycoumarin) and Benzopyrano-Coumarin Derivatives: Synthesis, 1H/13C-NMR Conformational and X-ray Crystal Structure Studies and In Vitro Antiviral Activity Evaluations

We report on the synthesis of 4-hydroxycoumarin dimers 1–15 bearing an aryl substituent on the central linker and fused benzopyranocoumarin derivatives 16–20 and on their in vitro broad anti-DNA and RNA virus activity evaluations. The chemical identities and structure of compounds 1–20 were deduced...

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Bibliographic Details
Main Authors: Janez Plavec, Mario Cetina, Jan Balzarini, Mladen Mintas, Erik De Clercq, Ante Nagl, Samija Muratović, Damjan Makuc, Davorka Završnik
Format: Article
Language:English
Published: MDPI AG 2011-07-01
Series:Molecules
Subjects:
4-hydroxycoumarin
benzopyranocoumarin
antiviral activity
1H/13C-NMR conformational study
X-ray diffraction
Online Access:http://www.mdpi.com/1420-3049/16/7/6023/

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