Aggregation activity of blood formed elements in patients with type 1 and type 2 diabetes mellitus

• Main Authors: Boris Il'ich Kuznik, Yury Antonovich Vitkovskiy, Marina Yur'evna Zakharova, Natalya Nikolaevna Klyuchereva, Olga Sergeevna Rodnina, Aleksey Vladimirovich Solpov
• Format: Article
• Language: English
• Published: Endocrinology Research Centre 2012-06-01
• Series: Сахарный диабет
• Subjects: platelets; leukocytes; lymphocytes; erythrocytes; aggregation; adhesion; diabetes mellitus
• Online Access: https://dia-endojournals.ru/dia/article/viewFile/5518/3316

Aims. To assess differences in blood formed elements aggregation activity in patients with type 1 (T1) and type 2 (T2) diabetes mellitus(DM). Materials and methods. We studied blood samples from 88 patients with T1 and T2 DM. Platelet aggregation activity was assessed bymeans of ?Biola? aggregometer; we also determined platelet-lymphocyte and leucocyte-erythrocyte adhesion intensity. Results. We show that spontaneous platelet aggregation is markedly increased in patients with T1DM but remains normal or slightlyelevated in case of T2DM. In blood from patients with T2DM platelet aggregation in response to ADP, epinephrine, ristomycineand contact with collagen was generally increased, whereas in T1DM we often observed its secondary reduction. Data on plateletlymphocyteadhesion in T1DM is controversial, but in T2DM this process seems to be significantly suppressed. Quantity of leucocyteerythrocyteaggregates was sharply increased in both T1DM and T2DM. Conclusion. We've determined significant difference in blood formed elements aggregation activity between patients with T1 and T2 DM.