Downregulation of signal transduction and STAT3 expression exacerbates oxidative stress mediated by NLRP3 inflammasome

Downregulation of signal transduction and STAT3 expression exacerbates oxidative stress mediated by NLRP3 inflammasome

Activated nucleotide binding to the oligonucleotide receptor protein 3 (NLRP3) inflammasome is possibly involved in the pathogenesis of Alzheimer's disease through oxidative stress and neurogenic inflammation. Low expression of the signal transducer and activator of transcription 3 (STAT3) gene...

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Bibliographic Details
Main Authors: Hua Bai, Qi-Fang Zhang, Juan-Juan Duan, De-Jun Yu, Li-Jie Liu
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2018-01-01
Series:Neural Regeneration Research
Subjects:
nerve regeneration; signal transducer and activator of transcription 3; calcium; caspase-1; nucleotide binding to the oligonucleotide receptor protein 3; inflammasome; hydrogen peroxide; Alzheimer′s disease; shRNA; SHSY5Y cells; neural regeneration
Online Access:http://www.nrronline.org/article.asp?issn=1673-5374;year=2018;volume=13;issue=12;spage=2147;epage=2155;aulast=Bai

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