Therapeutic Effect of Agaricus brasiliensis on Phenylhydrazine-Induced Neonatal Jaundice in Rats

Therapeutic Effect of Agaricus brasiliensis on Phenylhydrazine-Induced Neonatal Jaundice in Rats

The present study was designed to investigate the effect of Agaricus brasiliensis extract (ABE) on phenylhydrazine-induced neonatal jaundice in rats. Administration of ABE dose-dependently reduced the elevated bilirubin level induced by phenylhydrazine. It can be somewhat supported from the results...

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Main Authors: Lan Zhang, Bo Yuan, HuiPing Wang, Ya Gao
Format: Article
Language:English
Published: Hindawi Limited 2015-01-01
Series:BioMed Research International
Online Access:http://dx.doi.org/10.1155/2015/651218
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spelling doaj-c5152e8d9e724f93b791800e1d46387d2020-11-24T22:46:56ZengHindawi LimitedBioMed Research International2314-61332314-61412015-01-01201510.1155/2015/651218651218Therapeutic Effect of Agaricus brasiliensis on Phenylhydrazine-Induced Neonatal Jaundice in RatsLan Zhang0Bo Yuan1HuiPing Wang2Ya Gao3Department of Pediatrics, Second Hospital of Xi’an Jiaotong University, Xi’an 710004, ChinaXi’an Central Hospital, Xi’an 710003, ChinaDepartment of Pediatrics, Second Hospital of Xi’an Jiaotong University, Xi’an 710004, ChinaDepartment of Pediatrics, Second Hospital of Xi’an Jiaotong University, Xi’an 710004, ChinaThe present study was designed to investigate the effect of Agaricus brasiliensis extract (ABE) on phenylhydrazine-induced neonatal jaundice in rats. Administration of ABE dose-dependently reduced the elevated bilirubin level induced by phenylhydrazine. It can be somewhat supported from the results of in vitro bilirubin degradation experiment. ABE treatment also reduced the total antioxidant status (TAOS), cascade O2-/SOD, level of NF-κB protein, and adrenomedullin (AM). Overall, the results of this study demonstrated that Agaricus brasiliensis extract may be beneficial to reducing bilirubin level without causing hepatotoxicity in neonatal jaundice.http://dx.doi.org/10.1155/2015/651218
collection DOAJ
language English
format Article
sources DOAJ
author Lan Zhang
Bo Yuan
HuiPing Wang
Ya Gao
spellingShingle Lan Zhang
Bo Yuan
HuiPing Wang
Ya Gao
Therapeutic Effect of Agaricus brasiliensis on Phenylhydrazine-Induced Neonatal Jaundice in Rats
BioMed Research International
author_facet Lan Zhang
Bo Yuan
HuiPing Wang
Ya Gao
author_sort Lan Zhang
title Therapeutic Effect of Agaricus brasiliensis on Phenylhydrazine-Induced Neonatal Jaundice in Rats
title_short Therapeutic Effect of Agaricus brasiliensis on Phenylhydrazine-Induced Neonatal Jaundice in Rats
title_full Therapeutic Effect of Agaricus brasiliensis on Phenylhydrazine-Induced Neonatal Jaundice in Rats
title_fullStr Therapeutic Effect of Agaricus brasiliensis on Phenylhydrazine-Induced Neonatal Jaundice in Rats
title_full_unstemmed Therapeutic Effect of Agaricus brasiliensis on Phenylhydrazine-Induced Neonatal Jaundice in Rats
title_sort therapeutic effect of agaricus brasiliensis on phenylhydrazine-induced neonatal jaundice in rats
publisher Hindawi Limited
series BioMed Research International
issn 2314-6133
2314-6141
publishDate 2015-01-01
description The present study was designed to investigate the effect of Agaricus brasiliensis extract (ABE) on phenylhydrazine-induced neonatal jaundice in rats. Administration of ABE dose-dependently reduced the elevated bilirubin level induced by phenylhydrazine. It can be somewhat supported from the results of in vitro bilirubin degradation experiment. ABE treatment also reduced the total antioxidant status (TAOS), cascade O2-/SOD, level of NF-κB protein, and adrenomedullin (AM). Overall, the results of this study demonstrated that Agaricus brasiliensis extract may be beneficial to reducing bilirubin level without causing hepatotoxicity in neonatal jaundice.
url http://dx.doi.org/10.1155/2015/651218
work_keys_str_mv AT lanzhang therapeuticeffectofagaricusbrasiliensisonphenylhydrazineinducedneonataljaundiceinrats
AT boyuan therapeuticeffectofagaricusbrasiliensisonphenylhydrazineinducedneonataljaundiceinrats
AT huipingwang therapeuticeffectofagaricusbrasiliensisonphenylhydrazineinducedneonataljaundiceinrats
AT yagao therapeuticeffectofagaricusbrasiliensisonphenylhydrazineinducedneonataljaundiceinrats
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