Time-Restricted G-Protein Signaling Pathways via GPR176, G<sub>z</sub>, and RGS16 Set the Pace of the Master Circadian Clock in the Suprachiasmatic Nucleus

Time-Restricted G-Protein Signaling Pathways via GPR176, G<sub>z</sub>, and RGS16 Set the Pace of the Master Circadian Clock in the Suprachiasmatic Nucleus

G-protein-coupled receptors (GPCRs) are an important source of drug targets with diverse therapeutic applications. However, there are still more than one hundred orphan GPCRs, whose ligands and functions remain unidentified. The suprachiasmatic nucleus (SCN) is the central circadian clock of the bra...

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Bibliographic Details
Main Authors: Shumpei Nakagawa, Khanh Tien Nguyen Pham, Xinyan Shao, Masao Doi
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:International Journal of Molecular Sciences
Subjects:
circadian clock
orphan GPCR
suprachiasmatic nucleus
GPR176
G-protein
RGS16
Online Access:https://www.mdpi.com/1422-0067/21/14/5055

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https://www.mdpi.com/1422-0067/21/14/5055

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