The Rad4(TopBP1) ATR-activation domain functions in G1/S phase in a chromatin-dependent manner.

The Rad4(TopBP1) ATR-activation domain functions in G1/S phase in a chromatin-dependent manner.

DNA damage checkpoint activation can be subdivided in two steps: initial activation and signal amplification. The events distinguishing these two phases and their genetic determinants remain obscure. TopBP1, a mediator protein containing multiple BRCT domains, binds to and activates the ATR/ATRIP co...

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Bibliographic Details
Main Authors: Su-Jiun Lin, Christopher P Wardlaw, Takashi Morishita, Izumi Miyabe, Charly Chahwan, Thomas Caspari, Ulrike Schmidt, Antony M Carr, Valerie Garcia
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-06-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3386226?pdf=render

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