Notch2 controls non-autonomous Wnt-signalling in chronic lymphocytic leukaemia
The Wnt pathway is one of the core de-regulated pathways in chronic lymphocytic leukaemia (CLL) and is activated in only a subset of patients; however, no universal drivers of the disease have been identified. Here the authors show that Notch2 and β-catenin pathways are the main drivers of the pro-s...
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Bibliographic Details
| Main Authors: |
Maurizio Mangolini,
Frederik Götte,
Andrew Moore,
Tim Ammon,
Madlen Oelsner,
Gloria Lutzny-Geier,
Ludger Klein-Hitpass,
James C. Williamson,
Paul J. Lehner,
Jan Dürig,
Michael Möllmann,
Lívia Rásó-Barnett,
Katherine Hughes,
Antonella Santoro,
Simón Méndez-Ferrer,
Robert A. J. Oostendorp,
Ursula Zimber-Strobl,
Christian Peschel,
Daniel J. Hodson,
Marc Schmidt-Supprian,
Ingo Ringshausen |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2018-09-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-018-06069-5
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