Applications and Prospects of Microfluidic Chips in Orthopaedic Diseases

With the advent of an ageing society, bone-related diseases such as osteoporosis have become a major human health issue, and osteolytic lesions caused by cancer bone metastasis have always had a poor prognosis. Researchers have studied the pathogenesis of these orthopaedic diseases to obtain efficac...

Full description

Bibliographic Details
Main Authors:	Xiran Yang, Qiangqiang Tang, Chen Lai, Kai Wu, Xuetao Shi
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-01-01
Series:	Frontiers in Materials
Subjects:	microfluidics chip bone microenvironment osteoporosis bone metastasis
Online Access:	https://www.frontiersin.org/articles/10.3389/fmats.2020.610558/full

id	doaj-c4ec737066f34d43bd76fa64d690b92a
record_format	Article
spelling	doaj-c4ec737066f34d43bd76fa64d690b92a2021-01-12T17:00:34ZengFrontiers Media S.A.Frontiers in Materials2296-80162021-01-01710.3389/fmats.2020.610558610558Applications and Prospects of Microfluidic Chips in Orthopaedic DiseasesXiran Yang0Xiran Yang1Qiangqiang Tang2Qiangqiang Tang3Qiangqiang Tang4Chen Lai5Kai Wu6Xuetao Shi7Xuetao Shi8Xuetao Shi9Xuetao Shi10Peking University Shenzhen Institute, Peking University, Shenzhen, ChinaSchool of Materials Science and Engineering, South China University of Technology, Guangzhou, ChinaSchool of Materials Science and Engineering, South China University of Technology, Guangzhou, ChinaNational Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou, ChinaGuangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou, ChinaPeking University Shenzhen Institute, Peking University, Shenzhen, ChinaNational Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou, ChinaPeking University Shenzhen Institute, Peking University, Shenzhen, ChinaSchool of Materials Science and Engineering, South China University of Technology, Guangzhou, ChinaNational Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou, ChinaGuangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou, ChinaWith the advent of an ageing society, bone-related diseases such as osteoporosis have become a major human health issue, and osteolytic lesions caused by cancer bone metastasis have always had a poor prognosis. Researchers have studied the pathogenesis of these orthopaedic diseases to obtain efficacious treatments. Microfluidic chip technology is a popular technology developed in recent years. This technology can build an experimental platform for a bionic in vivo microenvironment in vitro, which has been favored by an increasing number of researchers. In this review, we will take osteoporosis and cancer bone metastasis as examples to illustrate the pathogenesis, introduce the latest progress in the research of orthopaedics-related diseases of the microfluidic model, and describe the current approaches and their limitations.https://www.frontiersin.org/articles/10.3389/fmats.2020.610558/fullmicrofluidicschipbone microenvironmentosteoporosisbone metastasis
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Xiran Yang Xiran Yang Qiangqiang Tang Qiangqiang Tang Qiangqiang Tang Chen Lai Kai Wu Xuetao Shi Xuetao Shi Xuetao Shi Xuetao Shi
spellingShingle	Xiran Yang Xiran Yang Qiangqiang Tang Qiangqiang Tang Qiangqiang Tang Chen Lai Kai Wu Xuetao Shi Xuetao Shi Xuetao Shi Xuetao Shi Applications and Prospects of Microfluidic Chips in Orthopaedic Diseases Frontiers in Materials microfluidics chip bone microenvironment osteoporosis bone metastasis
author_facet	Xiran Yang Xiran Yang Qiangqiang Tang Qiangqiang Tang Qiangqiang Tang Chen Lai Kai Wu Xuetao Shi Xuetao Shi Xuetao Shi Xuetao Shi
author_sort	Xiran Yang
title	Applications and Prospects of Microfluidic Chips in Orthopaedic Diseases
title_short	Applications and Prospects of Microfluidic Chips in Orthopaedic Diseases
title_full	Applications and Prospects of Microfluidic Chips in Orthopaedic Diseases
title_fullStr	Applications and Prospects of Microfluidic Chips in Orthopaedic Diseases
title_full_unstemmed	Applications and Prospects of Microfluidic Chips in Orthopaedic Diseases
title_sort	applications and prospects of microfluidic chips in orthopaedic diseases
publisher	Frontiers Media S.A.
series	Frontiers in Materials
issn	2296-8016
publishDate	2021-01-01
description	With the advent of an ageing society, bone-related diseases such as osteoporosis have become a major human health issue, and osteolytic lesions caused by cancer bone metastasis have always had a poor prognosis. Researchers have studied the pathogenesis of these orthopaedic diseases to obtain efficacious treatments. Microfluidic chip technology is a popular technology developed in recent years. This technology can build an experimental platform for a bionic in vivo microenvironment in vitro, which has been favored by an increasing number of researchers. In this review, we will take osteoporosis and cancer bone metastasis as examples to illustrate the pathogenesis, introduce the latest progress in the research of orthopaedics-related diseases of the microfluidic model, and describe the current approaches and their limitations.
topic	microfluidics chip bone microenvironment osteoporosis bone metastasis
url	https://www.frontiersin.org/articles/10.3389/fmats.2020.610558/full
work_keys_str_mv	AT xiranyang applicationsandprospectsofmicrofluidicchipsinorthopaedicdiseases AT xiranyang applicationsandprospectsofmicrofluidicchipsinorthopaedicdiseases AT qiangqiangtang applicationsandprospectsofmicrofluidicchipsinorthopaedicdiseases AT qiangqiangtang applicationsandprospectsofmicrofluidicchipsinorthopaedicdiseases AT qiangqiangtang applicationsandprospectsofmicrofluidicchipsinorthopaedicdiseases AT chenlai applicationsandprospectsofmicrofluidicchipsinorthopaedicdiseases AT kaiwu applicationsandprospectsofmicrofluidicchipsinorthopaedicdiseases AT xuetaoshi applicationsandprospectsofmicrofluidicchipsinorthopaedicdiseases AT xuetaoshi applicationsandprospectsofmicrofluidicchipsinorthopaedicdiseases AT xuetaoshi applicationsandprospectsofmicrofluidicchipsinorthopaedicdiseases AT xuetaoshi applicationsandprospectsofmicrofluidicchipsinorthopaedicdiseases
_version_	1724340375370334208

Applications and Prospects of Microfluidic Chips in Orthopaedic Diseases

Similar Items