Dihydromyricetin Protects Against Gentamicin-Induced Ototoxicity via PGC-1α/SIRT3 Signaling in vitro

Dihydromyricetin Protects Against Gentamicin-Induced Ototoxicity via PGC-1α/SIRT3 Signaling in vitro

Aminoglycoside-induced ototoxicity can have a major impact on patients’ quality of life and social development problems. Oxidative stress affects normal physiologic functions and has been implicated in aminoglycoside-induced inner ear injury. Excessive accumulation of reactive oxygen species (ROS) d...

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Bibliographic Details
Main Authors: Hezhou Han, Yaodong Dong, Xiulan Ma
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
dihydromyricetin
aminoglycosides
ototoxicity
PGC-1α
sirtuin 3
reactive oxygen species
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.00702/full

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