Genome-wide signatures of transcription factor activity: connecting transcription factors, disease, and small molecules.

Genome-wide signatures of transcription factor activity: connecting transcription factors, disease, and small molecules.

Identifying transcription factors (TF) involved in producing a genome-wide transcriptional profile is an essential step in building mechanistic model that can explain observed gene expression data. We developed a statistical framework for constructing genome-wide signatures of TF activity, and for u...

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Bibliographic Details
Main Authors: Jing Chen, Zhen Hu, Mukta Phatak, John Reichard, Johannes M Freudenberg, Siva Sivaganesan, Mario Medvedovic
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS Computational Biology
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24039560/pdf/?tool=EBI

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