Diagnostic Accuracy and Prognostic Value of Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios in Septic Patients outside the Intensive Care Unit

• Main Authors: Silvia Spoto, Domenica Marika Lupoi, Emanuele Valeriani, Marta Fogolari, Luciana Locorriere, Giuseppina Beretta Anguissola, Giulia Battifoglia, Damiano Caputo, Alessandro Coppola, Sebastiano Costantino, Massimo Ciccozzi, Silvia Angeletti
• Format: Article
• Language: English
• Published: MDPI AG 2021-08-01
• Series: Medicina
• Subjects: neutrophil-to-lymphocyte; platelet-to-lymphocyte; C-reactive protein; procalcitonin; MRproAdrenomedullin; systemic inflammatory response syndrome
• Online Access: https://www.mdpi.com/1648-9144/57/8/811
• ISSN: 1010-660X; 1648-9144

<i>Background and Objectives</i>: The aim of this study was to evaluate the diagnostic accuracy and prognostic value of neutrophil-to-lymphocyte (NLR) and platelet-to-lymphocyte (PLR) ratios and to compare them with other biomarkers and clinical scores of sepsis outside the intensive care unit. <i>Materials and methods</i>: In this retrospective study, 251 patients with sepsis and 126 patients with infection other than sepsis were enrolled. NLR and PLR were calculated as the ratio between absolute values of neutrophils, lymphocytes, and platelets by complete blood counts performed on whole blood by <i>Sysmex</i> XE-9000 (Dasit, Italy) following the manufacturer’s instruction. <i>Results</i>: The best NLR value in diagnosis of sepsis was 7.97 with sensibility, specificity, AUC, PPV, and NPV of 64.26%, 80.16%, 0.74 (<i>p</i> < 0.001), 86.49%, and 53.18%, respectively. The diagnostic role of NLR significantly increases when PLR, C-reactive protein (PCR), procalcitonin (PCT), and mid-regional pro-adrenomedullin (MR-proADM) values, as well as systemic inflammatory re-sponse syndrome (SIRS), sequential organ failure assessment (SOFA), and quick-sequential organ failure assessment (qSOFA) scores, were added to the model. The best value of NLR in predicting 90-day mortality was 9.05 with sensibility, specificity, AUC, PPV, and NPV of 69.57%, 61.44%, 0.66 (<i>p</i> < 0.0001), 28.9%, and 89.9%, respectively. Sensibility, specificity, AUC, PPV, and NPV of NLR increase if PLR, PCR, PCT, MR-proADM, SIRS, qSOFA, and SOFA scores are added to NLR. <i>Conclusions</i>: NLR and PLR represent a widely useful and cheap tool in diagnosis and in predict-ing 90-day mortality in patients with sepsis.