Identification of N-Acetyldopamine Dimers from the Dung Beetle Catharsius molossus and Their COX-1 and COX-2 Inhibitory Activities

Identification of N-Acetyldopamine Dimers from the Dung Beetle Catharsius molossus and Their COX-1 and COX-2 Inhibitory Activities

Recent studies focusing on identifying the biological agents of Catharsius molossus have led to the identification of three new N-acetyldopamine dimers molossusamide A–C (1-3) and two known compounds 4 and 5. The structures of the new compounds were identified by comprehensive spectroscopic evidence...

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Bibliographic Details
Main Authors: Juan Lu, Qin Sun, Zheng-Chao Tu, Qing Lv, Pi-Xian Shui, Yong-Xian Cheng
Format: Article
Language:English
Published: MDPI AG 2015-08-01
Series:Molecules
Subjects:
Catharsius molossus
N-acetyldopamine dimers
COX-1
COX-2
Online Access:http://www.mdpi.com/1420-3049/20/9/15589
Description
Summary:Recent studies focusing on identifying the biological agents of Catharsius molossus have led to the identification of three new N-acetyldopamine dimers molossusamide A–C (1-3) and two known compounds 4 and 5. The structures of the new compounds were identified by comprehensive spectroscopic evidences. Compound 4 was found to have inhibitory effects towards COX-1 and COX-2.
ISSN:1420-3049

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