Chemokine Receptor 2 (CXCR2) Gene Polymorphisms and Their Association with the Risk of Developing Peri-Implantitis in Chinese Han Population

• Main Authors: Qi Y, Li C, Du Y, Lin J, Li N, Yu Y
• Format: Article
• Language: English
• Published: Dove Medical Press 2021-04-01
• Series: Journal of Inflammation Research
• Subjects: chemokine receptor 2 (cxcr2); polymorphism; peri-implantitis; han population
• Online Access: https://www.dovepress.com/chemokine-receptor-2-cxcr2-gene-polymorphisms-and-their-association-wi-peer-reviewed-fulltext-article-JIR
• ISSN: 1178-7031

Yuesun Qi,1,2,* Cheng Li,1,3,* Yimin Du,2 Jichao Lin,1 Nan Li,2 Youcheng Yu1 1Department of Stomatology, Zhongshan Hospital, Fudan University, Shanghai, 200032, People’s Republic of China; 2Department of Stomatology, Jinshan Hospital, Fudan University, Shanghai, 200540, People’s Republic of China; 3Department of Stomatology, Jing’an District Institute of Dental Diseases, Shanghai, 200040, People’s Republic of China*These authors contributed equally to this workCorrespondence: Youcheng YuDepartment of Stomatology, Zhongshan Hospital, Fudan University, No. 180 Fenglin Road, Xuhui District, Shanghai, 200032, People’s Republic of ChinaTel/Fax [phone]Email [e-mail]: This study aimed to investigate the role of chemokine receptor 2 (CXCR2) gene polymorphisms in peri-implantitis susceptibility in a Chinese Han population.Patients and Methods: A total of 260 individuals were included in this study, including 127 peri-implantitis patients and 133 healthy implants. CXCR2 gene rs2230054 and rs1126580 polymorphisms in different groups were analyzed by the Chi-square test. The odds ratios (ORs) and 95% confidence intervals (95% CIs) were employed to evaluate the association between CXCR2 polymorphism and peri-implantitis susceptibility.Results: The CT genotype of rs2230054 and the AG genotype and G allele of rs1126580 significantly increased in peri-implantitis patients compared with healthy implants (P < 0.05). The CT genotype of rs2230054 (OR = 1.825, 95% CI = 1.028– 3.239) and the AG genotype of rs1126580 (OR = 2.223, 95% CI 1.272– 3.885) carriers had a high risk to infect with peri-implantitis. Additionally, these CXCR2 gene polymorphisms have been revealed to be associated with the periodontal status of peri-implantitis patients.Conclusion: The CXCR2 gene rs2230054 and rs1126580 polymorphisms were associated with the peri-implantitis susceptibility in the Chinese Han population. The CT genotype of rs2230054 and the AG genotype and G allele of rs1126580 serve as risk factors for the occurrence of peri-implantitis.Keywords: chemokine receptor 2, CXCR2, polymorphism, peri-implantitis, Han population