Isolated splenic high-grade serous carcinoma: A case report

Isolated splenic high-grade serous carcinoma: A case report

We present a unique case of high-grade serous carcinoma isolated to the spleen at the time of diagnosis, without any tumor present in the ovary, fallopian tubes, omentum or uterus, which was pathologically consistent with metastatic Mullerian carcinoma. Tumor sequencing with the MSK-IMPACT (Memorial...

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Bibliographic Details
Main Authors: Ralph Rogers, Sarah Ehmann, William P. Tew, Vance Broach
Format: Article
Language:English
Published: Elsevier 2021-08-01
Series:Gynecologic Oncology Reports
Subjects:
High-grade serous carcinoma
Splenic Mullerian carcinoma
Pluripotent spleen cell
TP53 hotspot mutation
PALB2 mutation
ARID1 somatic mutation
Online Access:http://www.sciencedirect.com/science/article/pii/S2352578921001223
Description
Summary:We present a unique case of high-grade serous carcinoma isolated to the spleen at the time of diagnosis, without any tumor present in the ovary, fallopian tubes, omentum or uterus, which was pathologically consistent with metastatic Mullerian carcinoma. Tumor sequencing with the MSK-IMPACT (Memorial Sloan Kettering–Integrated Mutation Profiling of Actionable Cancer Targets) multigene tumor panel test was performed, which revealed somatic mutations in PALB2 and in ARID1, as well as a TP53 hotspot mutation.
ISSN:2352-5789

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