Enhanced contextual fear memory in peroxiredoxin 6 knockout mice is associated with hyperactivation of MAPK signaling pathway

Enhanced contextual fear memory in peroxiredoxin 6 knockout mice is associated with hyperactivation of MAPK signaling pathway

Abstract Fear dysregulation is one of the symptoms found in post-traumatic stress disorder (PTSD) patients. The functional abnormality of the hippocampus is known to be implicated in the development of such pathology. Peroxiredoxin 6 (PRDX6) belongs to the peroxiredoxin family. This antioxidant enzy...

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Bibliographic Details
Main Authors: Sarayut Phasuk, Tanita Pairojana, Pavithra Suresh, Chee-Hing Yang, Sittiruk Roytrakul, Shun-Ping Huang, Chien-Chang Chen, Narawut Pakaprot, Supin Chompoopong, Sutisa Nudmamud-Thanoi, Ingrid Y. Liu
Format: Article
Language:English
Published: BMC 2021-02-01
Series:Molecular Brain
Subjects:
Peroxiredoxin 6
Trace fear conditioning
Fear memory
Posttraumatic stress disorder
MAPK signaling
Online Access:https://doi.org/10.1186/s13041-021-00754-1

Internet

https://doi.org/10.1186/s13041-021-00754-1

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